Chang Joon Lee

Title: Chang Joon Lee: Innovator in Pharmaceutical and Computational Chemistry

Introduction

Chang Joon Lee is a prominent inventor based in Seoul, South Korea. He has made significant contributions to the fields of pharmaceutical chemistry and computational methods. With a total of 2 patents, his work focuses on innovative solutions for treating malignant tumors and predicting activation energy in chemical reactions.

Latest Patents

One of his latest patents is titled "Phenothiazine derivatives having CaM inhibitory activity." This invention provides a phenothiazine derivative or a pharmaceutically acceptable salt thereof, along with a method for preparing the compound and a pharmaceutical composition containing it as an active ingredient. The phenothiazine derivative has been shown to inhibit calmodulin (CaM), which helps maintain high intracellular calcium levels in lung cancer cells, thereby aiding in the prevention or treatment of malignant tumors such as lung cancer.

Another notable patent is the "Method for predicting activation energy using atomic fingerprint descriptor or atomic descriptor." This invention outlines a method for constructing a database of atomic fingerprint descriptors. It includes steps for calculating the atomic fingerprint descriptor of a substrate, comparing it with a constructed database, and predicting activation energy for selected atomic positions using atomic descriptors. This method is particularly useful for predicting activation energy in cytochrome P450-mediated phase I metabolism.

Career Highlights

Chang Joon Lee has worked at esteemed institutions such as the Korea Institute of Science and Technology and the Bioinformatics & Molecular Design Research Center. His research has significantly advanced the understanding of chemical processes and therapeutic applications.

Collaborations

Throughout his career, Chang Joon Lee has collaborated with notable colleagues, including Eun Joo Roh and Bo Ra Mi Jeon. These collaborations have further enriched his research and contributed to the development of innovative solutions in his field.

Conclusion

Chang Joon Lee's contributions to pharmaceutical chemistry and computational methods highlight his role as a leading inventor. His innovative patents demonstrate a commitment to advancing medical science and improving treatment options for serious health conditions.