Company Filing History:
2 out of 469 
1 out of 88 
Years Active: 2022-2025
Title: Carolina L Haass-Koffler: Innovator in Neurobiology and Substance Use Disorder Treatment
Introduction
Carolina L Haass-Koffler is a prominent inventor based in Providence, RI (US). She has made significant contributions to the field of neurobiology, particularly in the modulation of corticotropin releasing factor binding protein and its implications for treating alcohol use disorder. With a total of 2 patents, her work is paving the way for innovative therapeutic approaches.
Latest Patents
Haass-Koffler's latest patents focus on compositions and methods for the modulation of the corticotropin releasing factor binding protein. Her research demonstrates that stress responses involve corticotropin releasing factor (CRF) and its binding protein (CRFBP). Utilizing a novel cell-based assay, she discovered that a C-terminal CRFBP fragment potentiates CRF-intracellular release, indicating that CRFBP has excitatory roles in addition to its previously established inhibitory functions. This research led to the identification of negative allosteric modulators (NAMs) that could potentially target N-Methyl-D-aspartic acid receptor (NMDAR)-mediated synaptic transmission in dopamine neurons, suggesting new avenues for treating stress and substance abuse disorders.
Career Highlights
Throughout her career, Carolina L Haass-Koffler has been involved in groundbreaking research that bridges the gap between neurobiology and clinical applications. Her innovative approaches have garnered attention in the scientific community, and her patents reflect her commitment to advancing our understanding of stress responses and substance use disorders.
Collaborations
Haass-Koffler has collaborated with esteemed institutions such as Brown University and Sanford Burnham Prebys Medical Discovery Institute. These partnerships have facilitated her research and contributed to the development of her innovative patents.
Conclusion
Carolina L Haass-Koffler is a trailblazer in the field of neurobiology, with her patents offering promising insights into the treatment of alcohol use disorder. Her work exemplifies the intersection of scientific research and practical application, making a significant impact on the future of therapeutic interventions.