Newcastle upon Tyne, United Kingdom

Carlos Estenio Hormaeche


Average Co-Inventor Count = 3.8

ph-index = 2

Forward Citations = 23(Granted Patents)


Company Filing History:


Years Active: 2000-2004

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3 patents (USPTO):Explore Patents

Title: Carlos Estenio Hormaeche: Innovator in Vaccine Development

Introduction

Carlos Estenio Hormaeche is a notable inventor based in Newcastle upon Tyne, GB. He has made significant contributions to the field of vaccine development, holding three patents that focus on innovative methods for expressing recombinant fusion proteins in attenuated bacteria.

Latest Patents

Hormaeche's latest patents include groundbreaking inventions such as the expression of recombinant fusion proteins in attenuated bacteria. This invention provides a DNA molecule that comprises a promoter sequence operably linked to a DNA sequence encoding first and second proteins linked by a hinge region. The promoter sequence can be one that is induced in response to environmental changes, and the first protein can be the Tetanus toxin C fragment or its epitopes. Additionally, the invention offers intermediate molecules with a promoter linked to a DNA sequence encoding a first antigenic sequence and a hinge region, along with restriction sites for introducing a second antigenic sequence. Another significant patent involves vaccine compositions that provide a DNA construct encoding a fusion protein of the formula: TetC-(Z)-Het. This construct includes the C fragment of tetanus toxin and a heterologous protein, with specific amino acid requirements. The invention also encompasses replicable expression vectors, transformed bacteria, and vaccine compositions derived from these fusion proteins.

Career Highlights

Throughout his career, Hormaeche has worked with prominent companies in the biotechnology sector, including Medeva Holdings BV and Acambis Research Limited. His work has significantly advanced the understanding and development of vaccines, particularly in the context of recombinant technologies.

Collaborations

Hormaeche has collaborated with notable professionals in his field, including Mohammed Anjam Khan and Steven Neville Chatfield. These collaborations have contributed to the successful development of his innovative vaccine technologies.

Conclusion

Carlos Estenio Hormaeche is a distinguished inventor whose work in vaccine development has had a profound impact on the field. His patents reflect a commitment to advancing medical science through innovative approaches to vaccine formulation and delivery.

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