Location History:
- Ann Arbor, MI (US) (1994 - 2022)
- Bohemia, NY (US) (2023)
Company Filing History:
2 out of 23 
1 out of 110 Years Active: 1994-2023
Title: The Innovative Contributions of Brad Neagle
Introduction
Brad Neagle is a notable inventor based in Ann Arbor, Michigan. He has made significant contributions to the field of cell imaging and analysis, holding three patents to his name. His work focuses on advancing the methods used to visualize and analyze live cell samples, which has important implications for biological research and medical applications.
Latest Patents
One of Brad Neagle's latest patents involves systems and methods for automatically imaging and analyzing cell samples in an incubator. This innovation utilizes an actuated microscope to generate images of samples within wells of a sample container over extended periods, such as days, weeks, or months. A plurality of images is produced for each scan of a particular well, allowing for detailed imaging and analysis of metabolically active cells. The analysis includes generating a 'range image' by subtracting the minimum intensity value across the scan for each pixel from the maximum intensity value. This technique emphasizes cells or portions of cells that exhibit changes in activity over time, such as neurons and cardiomyocytes, while de-emphasizing regions with consistently high intensities that may not be related to cell activity.
Career Highlights
Throughout his career, Brad Neagle has worked with reputable organizations, including Sartorius Bioanalytical Instruments, Inc. and the Environmental Research Institute of Michigan. His experience in these companies has contributed to his expertise in bioanalytical instruments and environmental research.
Collaborations
Brad has collaborated with notable colleagues, including Kirk S. Schroeder and Daniel Appledorn. These partnerships have likely enriched his work and contributed to the development of innovative solutions in his field.
Conclusion
Brad Neagle's contributions to live cell visualization and analysis demonstrate his commitment to advancing scientific research. His patents reflect a deep understanding of the complexities involved in cell imaging, making him a valuable figure in the field of biotechnology.