Company Filing History:
Years Active: 1977
Title: Bjarte Loken: Innovator in Steroid Chemistry
Introduction: Bjarte Loken is a prominent inventor based in Rho (Milan), Italy. Known for his significant contributions to the field of chemistry, particularly in steroid development, he holds one patent that revolutionizes the processing of steroid molecules.
Latest Patents: Bjarte Loken is the inventor of a groundbreaking patent titled "Trimethyl Siloxane Steroid Intermediates." This innovative procedure involves converting steroids with an 11.beta.OH group into potent corticoids with various substituents, including 6.alpha.F, 16.alpha., 17.alpha.-hydroxy or isopropylidene dioxy, and 16.alpha. or 16.beta. methyl. The methodology includes reacting the 11.beta.-hydroxy steroid with trichloromethyl siloxane steroid, which makes the 11 substituent inert during subsequent reactions to introduce the desired substituents. Following the process, the siloxy group is hydrolyzed to restore the 11.beta.-hydroxy substituent. The resulting trimethyl siloxy steroids represent novel compounds that contribute to the advancement of steroid chemistry.
Career Highlights: Bjarte Loken's career is marked by his association with the Steroid Development Company Establishment, where he applies his expertise in steroid synthesis and modification. His patent showcases his innovative approach and commitment to enhancing the efficacy of corticoids, demonstrating his valuable role in advancing pharmaceutical chemistry.
Collaborations: Throughout his career, Bjarte has worked alongside esteemed colleagues, including Peter Lindsay MacDonald and Ettore Bigatti. Their collaborative efforts have fostered advancements in steroid development, highlighting the importance of teamwork in the field of scientific research.
Conclusion: Bjarte Loken's contributions to the field of steroid chemistry through his innovative patent underscore his role as a significant inventor. His work not only enhances the understanding of steroid modifications but also paves the way for future advancements in pharmaceutical applications. As the landscape of steroid development continues to evolve, Bjarte remains a key player in driving innovation within this vital area of research.