Company Filing History:
3 out of 56 
2 out of 532 
1 out of 2,176 
Years Active: 1992-1999
Title: The Innovative Contributions of Bernard L Hirschbein
Introduction
Bernard L Hirschbein is a notable inventor based in San Francisco, CA, with a significant impact in the field of oligonucleotide synthesis. He holds a total of six patents, showcasing his expertise and innovative spirit in biochemistry and molecular biology.
Latest Patents
Hirschbein's latest patents include groundbreaking methods for synthesizing oligonucleotide N3'-P5' phosphoramidates. One of his inventions provides a method that utilizes an amine-exchange reaction of phosphoramidites. This method involves exchanging a deprotected 3'-amino group of a solid-phase supported oligonucleotide chain for the amino portion of a 5'-phosphoramidite of an incoming monomer. The resulting internucleotide phosphoramidite linkage is oxidized to form a stable protected phosphoramidate linkage. This innovative approach greatly improves product yields and reduces reagent usage compared to existing methods.
Another patent by Hirschbein focuses on the solid-phase synthesis of oligonucleotide N3'-P5' phosphoramidates, employing a similar amine-exchange reaction. This method also enhances product yields and minimizes reagent consumption, further establishing his contributions to the field.
Career Highlights
Throughout his career, Bernard L Hirschbein has worked with prominent companies such as Lynx Therapeutics, Inc. and Applied Biosystems, LLC. His experience in these organizations has allowed him to refine his skills and contribute to significant advancements in biotechnology.
Collaborations
Hirschbein has collaborated with esteemed colleagues, including Karen L Fearon and Wojciech J Stec. These partnerships have fostered a collaborative environment that encourages innovation and the sharing of ideas.
Conclusion
Bernard L Hirschbein's contributions to the field of oligonucleotide synthesis through his patents and collaborations highlight his role as a leading inventor. His innovative methods continue to influence the biotechnology industry and pave the way for future advancements.