Company Filing History:
Years Active: 2022
Title: Innovations of Benjamin Seelbinder in Cell Mechanics
Introduction
Benjamin Seelbinder is an innovative inventor based in Boulder, CO. He has made significant contributions to the field of cell mechanics through his research and inventions. His work focuses on understanding how cells respond to mechanical stimuli, which has important implications for various biological and medical applications.
Latest Patents
Benjamin Seelbinder holds a patent for "Methods and device for controlled cell stretch and imaging." This low-cost, magnetically-driven device enables visualization and quantification of dynamic changes in cell behavior during mechanical stretch. His research revealed that the nuclei of mouse embryonic skin fibroblasts exhibit rapid but divergent responses to different strain magnitudes. Specifically, during low strain (5%), the nuclei showed an increase in area and chromatin decompaction, while high strain (20%) resulted in a decrease in nuclear area and chromatin condensation. Notably, responses to low strain were calcium-dependent, whereas actin inhibition negated any nuclear response and increased stretch-induced DNA damage. The findings suggest that different pathways control strain level-dependent cell behavior, indicating that mechanical confinement of nuclei through actin may serve as a protective mechanism during high strain loads.
Career Highlights
Benjamin Seelbinder is affiliated with the University of Colorado, where he continues to advance research in cell mechanics. His innovative approach and findings have positioned him as a notable figure in the field.
Collaborations
He has collaborated with esteemed colleagues, including Corey Philip Neu and Adrienne K Scott, to further explore the implications of his research.
Conclusion
Benjamin Seelbinder's work in developing a device for controlled cell stretch and imaging represents a significant advancement in understanding cellular responses to mechanical forces. His contributions are paving the way for future research in cell mechanics and its applications in medicine.