Company Filing History:
Years Active: 2022-2025
Title: Innovations by Axel Bethke in Genomic Research
Introduction
Axel Bethke is a notable inventor based in Belmont, CA, who has made significant contributions to the field of genomic research. With a focus on methods for characterizing copy number variation, his work has implications for understanding genome rearrangements in biological samples. He holds 2 patents that showcase his innovative approaches to genomic analysis.
Latest Patents
Bethke's latest patents include groundbreaking methods for detecting genome rearrangement using proximity-ligation sequencing. One of the disclosed methods involves obtaining a contact matrix from proximity ligation sequencing data of at least one chromosome. This method identifies abnormal contact patterns in the contact matrix compared to a reference genome. Furthermore, it compares these patterns to known patterns associated with genomic rearrangement to identify the type of genomic rearrangement causing the abnormal contact pattern. Another method focuses on selecting linked chromosomal fragments from the same sequencing data, identifying abnormal covalent bonding patterns, and comparing them to reference genomes to identify genomic rearrangements.
Career Highlights
Axel Bethke is currently associated with Natera, Inc., a company that specializes in genetic testing and diagnostics. His work at Natera has allowed him to apply his innovative methods in a practical setting, contributing to advancements in genomic research and diagnostics.
Conclusion
Axel Bethke's contributions to genomic research through his innovative patents highlight the importance of advancements in understanding genetic variations. His work continues to pave the way for future discoveries in the field of genomics.