Arthur Henry Antoon Marie Van Onzen

Title: Arthur Henry Antoon Marie Van Onzen: Innovator in Bio-Orthogonal Drug Activation

Introduction

Arthur Henry Antoon Marie Van Onzen is a notable inventor based in Eindhoven, Netherlands. He has made significant contributions to the field of bio-orthogonal drug activation, showcasing his innovative spirit through his patent work. With a focus on advancing chemical cleavage techniques, Van Onzen's inventions have the potential to impact various applications in the pharmaceutical industry.

Latest Patents

Van Onzen holds a patent for a "Cleavable tetrazine used in bio-orthogonal drug activation." This invention discloses an advancement in provoked chemical cleavage. The invention provides the use of a diene as a chemically cleavable group attached to a construct, along with the use of a dienophile to provoke the release of the construct. This is achieved by allowing the diene to react with a dienophile capable of undergoing an inverse electron demand Diels-Alder reaction with the diene. The patent also includes a kit for releasing a construct bound to a trigger, where the kit contains a tetrazine and a dienophile, with the trigger being the tetrazine. Furthermore, the invention describes the formation of a pyridazine by reacting a tetrazine with a construct and a dienophile, serving as a chemical tool for the release of the construct in various environments.

Career Highlights

Throughout his career, Van Onzen has worked with several prominent companies, including Tagworks Pharmaceuticals B.V. and Syncom B.V. His experience in these organizations has allowed him to refine his skills and contribute to groundbreaking research in the field of drug activation.

Collaborations

Van Onzen has collaborated with notable individuals in his field, including Marc Stefan Robillard and Wolter Ten Hoeve. These partnerships have fostered innovation and have been instrumental in advancing their shared goals in pharmaceutical research.

Conclusion

Arthur Henry Antoon Marie Van Onzen is a distinguished inventor whose work in bio-orthogonal drug activation has the potential to revolutionize the pharmaceutical industry. His innovative approaches and collaborations highlight his commitment to advancing scientific knowledge and improving drug delivery systems.