Company Filing History:
2 out of 11 
1 out of 5 Years Active: 2006-2011
Title: Innovations in Cancer Treatment by Ann Y Kim
Introduction
Ann Y Kim is a prominent inventor based in Glendale, AZ, who has made significant contributions to the field of cancer research. With a total of three patents to her name, she has focused her work on developing anticancer agents that target the regulation of protein prenylation. Her innovative approaches aim to mitigate the growth of cancer cells, providing hope for more effective treatments.
Latest Patents
One of Ann Y Kim's latest patents involves anticancer agents based on the regulation of protein prenylation. Oncoproteins such as Ras and RhoB are known to induce uncontrolled cell division when localized at the inner surface of a cancer cell membrane. This localization is facilitated by the prenylation reaction, where a hydrophobic group, such as a farnesyl group, is attached to the protein in the presence of an enzyme like farnesyl protein transferase. By deactivating the prenylation enzyme through covalent modification, it is possible to mitigate or even cease cancer cell growth. The patent details various prenylation inhibitors that possess the necessary structural groups to bond covalently or irreversibly to the prenylation enzyme. These include carbonyl or thiocarbonyl compounds and alpha oxo-epoxides bonded to a hydrophobic, substrate-mimicking group, enhancing the tendency to form covalent bonds.
Career Highlights
Throughout her career, Ann Y Kim has worked with notable organizations such as the Arizona Biomedical Research Commission and the Arizona Disease Control Research Commission. Her work in these institutions has allowed her to advance her research and contribute to the understanding of cancer treatment.
Collaborations
Some of her coworkers include Seth David Rose and Scott R Lefler, who have collaborated with her on various projects related to cancer research.
Conclusion
Ann Y Kim's innovative work in the field of cancer treatment through the regulation of protein prenylation showcases her dedication to advancing medical science. Her contributions have the potential to lead to more effective therapies for cancer patients.