Ann E Campbell

Title: Ann E Campbell: Innovator in Cytomegalovirus Research

Introduction

Ann E Campbell is a distinguished inventor based in Norfolk, VA (US). She has made significant contributions to the field of virology, particularly in understanding the mechanisms of human cytomegalovirus (HCMV). With a total of four patents to her name, her work has advanced the scientific community's knowledge of viral infections and their impact on human health.

Latest Patents

Among her latest patents is a groundbreaking invention related to cells transformed or transfected with HCMV US2-US5 and US10-US11 genes. This invention addresses the infection of human fibroblast cells with HCMV, which causes downregulation of cell surface expression of MHC class I. The patent describes a mutant with a 9-kb deletion in the S component of the HCMV genome, which fails to downregulate class I heavy chains. By examining the phenotypes of mutants with smaller deletions, a 7-kb region containing at least nine open reading frames was identified as crucial for the reduction in heavy chain expression. Furthermore, it was determined that two subregions of this region each contained genes sufficient to cause heavy chain downregulation, with the US11 gene product playing a significant role.

Career Highlights

Throughout her career, Ann E Campbell has worked with notable organizations, including American Cyanamid Company and Eastern Virginia Medical School. Her research has not only contributed to her patents but has also enhanced the understanding of viral mechanisms in the medical community.

Collaborations

One of her prominent collaborators is Thomas Richard Jones, with whom she has worked on various research projects related to her field of expertise.

Conclusion

Ann E Campbell's innovative work in the field of cytomegalovirus research has led to significant advancements in understanding viral infections. Her contributions through patents and collaborations continue to impact the scientific community positively.