Company Filing History:
Years Active: 1993
Title: Andrzej Kolinski: Innovator in Protein Structure Determination
Introduction
Andrzej Kolinski is a notable inventor based in San Diego, California. He has made significant contributions to the field of computational biology, particularly in the determination of protein structures. His innovative approach utilizes advanced computational methods to simulate protein folding, which is crucial for understanding biological processes.
Latest Patents
Kolinski holds a patent for a "System and method for determining three-dimensional structures of proteins." This patent describes a computer system and method that determines a protein's tertiary structure from its primary sequence of amino acid residues. The system employs a dynamic Monte Carlo method with Metropolis sampling criterion and a selected (2,1,0) lattice model to simulate protein folding. It generates a folding trajectory that represents successive three-dimensional images of the protein at a resolution of two Angstroms as it transitions from an unfolded to a folded state. This innovative system allows for interaction between proximate pairs of sidechains and enhances processing speed through the use of a lattice.
Career Highlights
Kolinski is affiliated with the Scripps Clinic and Research Foundation, where he applies his expertise in computational methods to biological research. His work has implications for drug design and understanding diseases at a molecular level. He has been recognized for his contributions to the field and continues to advance research in protein structure determination.
Collaborations
Kolinski has collaborated with Jeffrey Skolnick, a fellow researcher in the field. Their partnership has led to advancements in computational techniques for studying protein structures.
Conclusion
Andrzej Kolinski's innovative work in protein structure determination exemplifies the intersection of technology and biology. His contributions are vital for advancing our understanding of molecular biology and have the potential to impact various applications in medicine and research.