Ana M Espino

Title: Innovations by Ana M Espino

Introduction

Ana M Espino is a prominent inventor based in San Juan, Puerto Rico. She has made significant contributions to the field of biomedical research, particularly in the development of anti-inflammatory molecules. With a total of 2 patents, her work focuses on addressing critical health issues related to inflammation and bacterial infections.

Latest Patents

Ana's latest patents include groundbreaking inventions that target the suppression of inflammatory responses. One of her notable inventions is titled "Recombinant Fasciola hepatica fatty acid binding protein suppresses toll-like receptor stimulation in response to multiple bacterial ligands." This invention provides a method for expressing and purifying a recombinant form of fatty acid binding protein (Fh15), which exhibits a suppressive effect on TLR-stimulation and inflammatory cytokine expression from macrophages. Fh15 has shown the ability to suppress the expression of IL-1β and TNFα in murine macrophages and THP1 Blue CD14 cells, making it a promising candidate for anti-inflammatory drug development.

Another significant patent is "Fatty acid binding protein a novel anti-inflammatory molecule." This invention addresses the need for molecules that can block the activation of Toll-like receptor 4 (TLR4), which plays a crucial role in inducing inflammatory responses. Ana's research demonstrates that a single intraperitoneal injection of 15 µg of fatty acid binding protein (Fh12) significantly suppresses the expression of serum inflammatory cytokines in a model of septic shock. This innovative approach could lead to new treatments for bacterial sepsis.

Career Highlights

Ana M Espino is affiliated with the University of Puerto Rico, where she conducts her research and develops her inventions. Her work has garnered attention for its potential impact on public health, particularly in the context of inflammatory diseases and bacterial infections.

Collaborations

Ana has collaborated with notable colleagues, including Ivelisse Martin and Marcos J Ramos-Benitez. These collaborations have contributed to the advancement of her research and the successful development of her patents.

Conclusion

Ana M Espino's innovative work in the field of anti-inflammatory research highlights her dedication to improving health outcomes. Her patents represent significant advancements in understanding and combating inflammation, showcasing her role as a leading inventor in her field.