Alexander Wentzel

Title: Alexander Wentzel: Innovator in Peptide Display Technology

Introduction

Alexander Wentzel is a notable inventor based in Göttingen, Germany. He has made significant contributions to the field of biotechnology, particularly in the area of peptide and polypeptide exposure on bacterial surfaces. His innovative methods have the potential to advance various applications in research and medicine.

Latest Patents

Wentzel holds a patent for a "Method for exposing peptides and polypeptides on the cell surface of bacteria." This inventive method allows for the effective display of peptides or polypeptides on the surface of gram-negative host bacteria using specific intimin-based anchor modules. Intimins with shortened carboxy terminals have been identified as particularly suitable anchor modules for passenger domains in the exterior cell membrane. The method involves transforming host bacteria using vectors that contain a fused nucleic acid sequence, which codes for an intimin with a shortened carboxy terminal and the passenger peptide to be exposed. This invention enables a large number of passenger domains to be displayed on the bacterial surface without compromising the bacteria's viability.

Career Highlights

Wentzel is associated with Nascacell Technologies AG, where he continues to develop and refine his innovative methods. His work has garnered attention for its potential applications in various biotechnological fields.

Collaborations

Some of his notable coworkers include Harald Kolmar and Andreas Christmann, who have collaborated with him on various projects related to peptide display technology.

Conclusion

Alexander Wentzel's contributions to biotechnology, particularly through his patented methods for peptide exposure on bacterial surfaces, highlight his role as an innovator in the field. His work promises to enhance the understanding and application of peptides in scientific research and medicine.