Company Filing History:
Years Active: 2022
Title: **The Innovations of Alberto Inga: High-Fidelity CAS9 Variants**
Introduction
Alberto Inga is a recognized inventor based in Trento, Italy. His significant contribution to the field of genetic engineering is encapsulated in his sole patent, which addresses the complexities associated with the CRISPR technology, specifically focusing on the CAS9 protein.
Latest Patents
Inga’s patent titled "High-fidelity CAS9 variants and applications thereof" seeks to tackle the limitations posed by nonspecific genomic cleavages of the traditional SpCas9. This innovative work includes a yeast-based assay to evaluate both on- and off-target activities simultaneously across two engineered genomic targets. By employing random mutagenesis of the Red-II domain, Inga successfully identified CAS9 variants that exhibit enhanced cleavage fidelity. The most notable of these is the evoCas9 variant, which was isolated by combining various mutations. Remarkably, this variant demonstrates a substantial improvement in fidelity compared to previously designed alternatives.
Career Highlights
Alberto Inga is affiliated with the University of Trento, where he has been instrumental in pioneering research in genetic modifications and improving gene-editing techniques. His academic and professional endeavors have helped to elevate the understanding and application of CRISPR technology in modern science.
Collaborations
Inga has worked alongside fellow researchers, specifically Anna Cereseto and Antonio Casini, in advancing genetic research. Their collaborative efforts have contributed to the validation and application of innovative solutions in the field of gene editing, further solidifying their impact on biotechnology.
Conclusion
Alberto Inga has made remarkable strides in the realm of genetic engineering through his inventive work on high-fidelity CAS9 variants. His research not only showcases the continual evolution of CRISPR technology but also its potential applications in various genetic research fields. His contributions have undoubtedly laid the groundwork for future innovations in genetic editing and biotechnology.