Albert De La Chapelle

Title: Albert De La Chapelle: A Pioneer in Genetic Research

Introduction

Albert De La Chapelle is a prominent inventor and researcher known for his significant contributions to the field of genetics. He is based in Helsingfors, Finland, and has been awarded a total of 10 patents throughout his career. His work has had a profound impact on understanding hereditary diseases, particularly colorectal cancer.

Latest Patents

One of his latest patents involves the identification of the human MSH2 gene, which is responsible for hereditary non-polyposis colorectal cancer. This gene was identified due to its homology to the MutS class of genes, which play a crucial role in DNA mismatch repair. The sequence of cDNA clones of the human gene is provided, and this sequence can be utilized to demonstrate the existence of germ line mutations in hereditary non-polyposis colorectal cancer (HNPCC) kindreds, as well as in replication error (RER) tumor cells. Another notable patent focuses on Cystatin B mutants, further showcasing his innovative research in genetics.

Career Highlights

Throughout his career, Albert De La Chapelle has worked with prestigious institutions such as Johns Hopkins University and Washington University. His research has not only advanced scientific knowledge but has also paved the way for new diagnostic and therapeutic approaches in genetics.

Collaborations

He has collaborated with esteemed colleagues in the field, including Bert Vogelstein and Kenneth W. Kinzler. These partnerships have contributed to the depth and breadth of his research, enhancing the impact of his findings.

Conclusion

Albert De La Chapelle's work in genetics has made him a key figure in the study of hereditary diseases. His innovative patents and collaborations have significantly advanced our understanding of genetic disorders, particularly in relation to colorectal cancer. His contributions continue to influence the field and inspire future research.