Alan M Pearson

Title: Alan M Pearson: Innovator in Scavenger Receptor Research

Introduction

Alan M Pearson is a notable inventor based in Somerville, MA (US). He has made significant contributions to the field of biochemistry, particularly in the study of scavenger receptors. His work has implications for understanding cholesterol uptake and its related health issues.

Latest Patents

Alan M Pearson holds a patent for "Class BI and CI scavenger receptors." This patent describes two distinct scavenger receptor type proteins that have a high affinity for modified lipoproteins and other ligands. The receptors, HaSR-BI and dSR-CI, have been isolated, characterized, and cloned. HaSR-BI is an AcLDL and LDL binding scavenger receptor, distinct from type I and type II macrophage scavenger receptors. It has been isolated and characterized, with DNA encoding the receptor cloned from a variant of Chinese Hamster Ovary Cells, designated Var-261. dSR-CI is a non-mammalian AcLDL binding scavenger receptor that exhibits high ligand affinity and broad specificity. These isolated receptors are valuable for screening drugs that inhibit cholesterol uptake in endothelial or adipose cells or macrophages. They also serve as probes for isolating other lipoprotein receptors and researching the roles of these receptors.

Career Highlights

Alan M Pearson is affiliated with the Massachusetts Institute of Technology, where he continues to advance research in his field. His innovative work has garnered attention and respect within the scientific community.

Collaborations

He has collaborated with notable colleagues, including Monty Krieger and Susan Laurene Acton, contributing to the advancement of knowledge in scavenger receptor research.

Conclusion

Alan M Pearson's contributions to the field of biochemistry, particularly through his patent on scavenger receptors, highlight his role as an influential inventor. His work continues to impact research and drug development related to cholesterol uptake.