Company Filing History:
Years Active: 1999
Title: Alan Charles Gough: Innovator in Genetic Assays
Introduction
Alan Charles Gough is a notable inventor based in Dorset, GB. He has made significant contributions to the field of genetic assays, particularly in understanding the polymorphisms of the cytochrome P450 enzyme. His work is crucial for determining drug metabolism phenotypes, which can impact patient care and treatment efficacy.
Latest Patents
Alan Gough holds a patent for a genetic assay that identifies polymorphisms at specific positions of the cytochrome P450 enzyme bufuralol-1'-hydroxylase. This patent is particularly relevant for distinguishing between extensive metaboliser and poor metaboliser phenotypes. The assay utilizes established methods such as DNA amplification through polymerase chain reaction, followed by digestion with a suitable restriction enzyme and analysis via gel electrophoresis. This innovation is vital for calculating safe or effective drug doses for individuals.
Career Highlights
Gough is associated with Imperial Cancer Research Technology, Ltd., where he applies his expertise in genetic research. His work has implications for personalized medicine, particularly in oncology, where understanding drug metabolism can lead to better treatment outcomes.
Collaborations
Alan has collaborated with notable colleagues, including Charles Roland Wolf and John Stephen Miles. Their combined efforts in research have contributed to advancements in genetic testing and drug metabolism studies.
Conclusion
Alan Charles Gough's contributions to genetic assays and drug metabolism are significant in the field of medical research. His innovative patent and collaborative efforts continue to influence the landscape of personalized medicine.