The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 05, 2018
Filed:
Apr. 22, 2008
Applicants:
Jose Manuel Gomes, Chelmsford, MA (US);
Gregory Walter Hiller, Wakefield, MA (US);
Inventors:
Jose Manuel Gomes, Chelmsford, MA (US);
Gregory Walter Hiller, Wakefield, MA (US);
Assignee:
Wyeth LLC, New York, NY (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12P 21/00 (2006.01); C12P 21/02 (2006.01); C07K 14/705 (2006.01);
U.S. Cl.
CPC ...
C12P 21/02 (2013.01); C07K 14/70578 (2013.01); C12P 21/005 (2013.01); C12N 2500/33 (2013.01); C12N 2510/02 (2013.01);
Abstract
The present disclosure provides a method of reducing protein misfolding and aggregation in the cell culture by growing the cell culture at a reduced temperature and/or reduced pH. As a result, the quality of the protein produced in the cell culture is greatly improved. Thus, the present disclosure facilitates improvements in the efficacy of therapeutic proteins produced in cell culture.