The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 22, 2018
Filed:
Mar. 23, 2017
Chugai Seiyaku Kabushiki Kaisha, Tokyo, JP;
Junichi Nezu, Shizuoka, JP;
Atsushi Narita, Shizuoka, JP;
Takahiro Ishiguro, Kanagawa, JP;
Mika Sakurai, Shizuoka, JP;
Hirotake Shiraiwa, Shizuoka, JP;
Naoka Hironiwa, Shizuoka, JP;
Tomoyuki Igawa, Shizuoka, JP;
Yumiko Kawai, Kanagawa, JP;
Chugai Seiyaku Kabushiki Kaisha, Tokyo, JP;
Abstract
Novel multispecific antigen-binding molecules maintaining excellent cellular cytotoxicity and high stability, which comprise a domain that contains an antibody variable region having glypican 3-binding activity and a domain that contains an antibody variable region having T-cell receptor complex-binding activity, were discovered. Since the molecules of the present invention show a strong cytotoxicity against cells and tissues expressing glypican 3, it is possible to produce novel pharmaceutical compositions for treating or preventing various cancers.