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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 9969975 B1

PDFFull Text
Date of Patent:
May. 15, 2018

Filed:

Jan. 08, 2018

Genetically-modified cells comprising a modified human t cell receptor alpha constant region gene

Applicant:

Precision Biosciences, Inc., Durham, NC (US);

Inventors:

Derek Jantz, Durham, NC (US);

James Jefferson Smith, Morrisville, NC (US);

Michael G. Nicholson, Chapel Hill, NC (US);

Daniel T. MacLeod, Durham, NC (US);

Jeyaraj Antony, Chapel Hill, NC (US);

Victor Bartsevich, Durham, NC (US);

Assignee:

Precision BioSciences, Inc., Durham, NC (US);

Attorney:

Wolf, Greenfield & Sacks, P.C.

Primary Examiner:

Kevin K Hill

Int. Cl.
CPC ...
A61K 35/17 (2015.01); C07K 16/30 (2006.01); C12N 15/09 (2006.01); C12N 5/0783 (2010.01); C07K 14/725 (2006.01); C07K 16/28 (2006.01); C12N 15/86 (2006.01);
U.S. Cl.
CPC ...
C12N 5/0636 (2013.01); C07K 14/7051 (2013.01); C07K 16/2803 (2013.01); C12N 15/86 (2013.01); C07K 2319/01 (2013.01); C07K 2319/02 (2013.01); C07K 2319/03 (2013.01); C12N 2510/00 (2013.01);
Abstract

Disclosed herein is a genetically-modified cell comprising in its genome a modified human T cell receptor alpha constant region gene, wherein the cell has reduced cell-surface expression of the endogenous T cell receptor. The present disclosure further relates to methods for producing such a genetically-modified cell, and to methods of using such a cell for treating a disease in a subject.

Find Patent Forward Citations

Jantz, Derek. (2018). Genetically-modified cells comprising a modified human t cell receptor alpha constant region gene (U.S. Patent No. 9969975). U.S. Patent and Trademark Office. https://idiyas.com/patent/badge/9969975

Data source: USPTO (United States Patent and Trademark Office) public patent records. Weekly synchronization. How IDiyas builds this profile

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