The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 08, 2018
Filed:
Oct. 15, 2013
Ionis Pharmaceuticals, Inc., Carlsbad, CA (US);
Ludwig Institute for Cancer Research, New York, NY (US);
The Regents of the University of California, Oakland, CA (US);
C. Frank Bennett, Carlsbad, CA (US);
Susan M. Freier, San Diego, CA (US);
Frank Rigo, Carlsbad, CA (US);
Don W. Cleveland, Del Mar, CA (US);
Clotilde Lagier-Tourenne, La Jolla, CA (US);
John M. Ravits, La Jolla, CA (US);
Michael W. Baughn, La Jolla, CA (US);
Ionis Pharmaceuticals, Inc., Carlsbad, CA (US);
Ludwig Institute for Cancer Research, New York, NY (US);
The Regents of the University of California, Oakland, CA (US);
Abstract
Disclosed herein are methods for reducing expression of C90RF72 mRNA and protein in an animal with C90RF72 specific inhibitors. Such methods are useful to treat, prevent, or ameliorate neurodegenerative diseases in an individual in need thereof. Such C90RF72 specific inhibitors include antisense compounds. Examples of neurodegenerative diseases that can be treated, prevented, and ameliorated with the administration C90RF72 specific inhibitors include amyotrophic lateral sclerosis (ALS), frontotemporal dementia (FTD), corticalbasal degeneration syndrome (CBD), atypical Parkinsonian syndrome, and olivopontocerellar degeneration (OPCD).