The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
May. 01, 2018

Filed:

Aug. 20, 2010
Applicants:

John E. Mcbride, Lyme, NH (US);

Vineet Rajgarhia, Dublin, CA (US);

Arthur J. Shaw, Iv, Grantham, NH (US);

Shital A. Tripathi, Berkeley, CA (US);

Elena Brevnova, Lebanon, NH (US);

Nicky Caiazza, Lebanon, NH (US);

Johannes Pieter Van Dijken, Schiedam, NL;

Allan C. Froehlich, Lebanon, NH (US);

William Ryan Sillers, Lebanon, NH (US);

James H. Flatt, Del Mar, CA (US);

Inventors:

John E. McBride, Lyme, NH (US);

Vineet Rajgarhia, Dublin, CA (US);

Arthur J. Shaw, IV, Grantham, NH (US);

Shital A. Tripathi, Berkeley, CA (US);

Elena Brevnova, Lebanon, NH (US);

Nicky Caiazza, Lebanon, NH (US);

Johannes Pieter Van Dijken, Schiedam, NL;

Allan C. Froehlich, Lebanon, NH (US);

William Ryan Sillers, Lebanon, NH (US);

James H. Flatt, Del Mar, CA (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12N 1/00 (2006.01); C12N 1/20 (2006.01); C12P 7/04 (2006.01); C12P 7/18 (2006.01); C12Q 1/00 (2006.01); C12Q 1/68 (2006.01); C07H 21/04 (2006.01); C12P 7/36 (2006.01);
U.S. Cl.
CPC ...
C12P 7/18 (2013.01); C12P 7/04 (2013.01); C12P 7/36 (2013.01); C12P 2203/00 (2013.01);
Abstract

The present invention provides for novel metabolic pathways leading to propanol, alcohol or polyol formation in a consolidated bioprocessing system (CBP), where lignocellulosic biomass is efficiently converted to such products. More specifically, the invention provides for a recombinant microorganism, where the microorganism expresses one or more native and/or heterologous enzymes; where the one or more enzymes function in one or more engineered metabolic pathways to achieve: (1) conversion of a carbohydrate source to 1,2-propanediol, isopropropanol, ethanol and/or glycerol; (2) conversion of a carbohydrate source to n-propanol and isopropanol; (3) conversion of a carbohydrate source to isopropanol and methanol; or (4) conversion of a carbohydrate source to propanediol and acetone; wherein the one or more native and/or heterologous enzymes is activated, upregulated or downregulated.


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