The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 01, 2018
Filed:
Jul. 23, 2015
Applicants:
Shire Human Genetic Therapies, Inc., Lexington, MA (US);
Fondazione Telethon, Rome, IT;
Inventors:
Muthuraman Meiyappan, Lexington, MA (US);
Maria A. DeMatteis, Rome, IT;
Assignees:
SHIRE HUMAN GENETIC THERAPIES, INC., Lexington, MA (US);
FONDAZIONE TELETHON, Roma, IT;
Attorneys:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C12N 9/36 (2006.01); G01N 33/68 (2006.01); G06F 19/12 (2011.01); G06F 19/16 (2011.01);
U.S. Cl.
CPC ...
C12N 9/2462 (2013.01); C12Y 302/01017 (2013.01); G01N 33/6803 (2013.01); G06F 19/12 (2013.01); G06F 19/16 (2013.01);
Abstract
In some embodiments, the present invention provides method of identifying compounds that bind to phosphoinositol 4-phosphate adaptor protein-2 (FAPP2), including the steps of computationally identifying a compound that binds to FAPP2 using the atomic coordinates of at least the amino acids which make up the substrate binding pocket of FAPP2. Also provided are methods of designing, selecting and/or optimizing a compound that binds to FAPP2.