The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 24, 2018
Filed:
Jun. 17, 2014
The University of North Carolina AT Chapel Hill, Chapel Hill, NC (US);
Rensselaer Polytechnic Institute, Troy, NY (US);
Nutech Ventures, Lincoln, NE (US);
Jian Liu, Chapel Hill, NC (US);
Yongmei Xu, Durham, NC (US);
Robert J. Linhardt, Albany, NY (US);
Edward Harris, Lincoln, NE (US);
The University of North Carolina at Chapel Hill, Chapel Hill, NC (US);
Rensselaer Polyechnic Institute, Troy, NY (US);
NUtech Ventures, Lincoln, NE (US);
Abstract
Methods and systems for synthesizing heparin compounds are provided. The chemoenzymatic synthesis of structurally homogeneous low molecular weight heparins that have a reversible anticoagulant activity is provided. Also disclosed are heparin compounds having anticoagulant activity, including a binding affinity to antithrombin and an anti-Xa activity, but no detectable anti-lla activity. Additionally, provided are synthetic, low-molecular weight heparin compounds with reversible anticoagulant activity, where the anticoagulant activity is reversible by protamine.