The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Apr. 24, 2018

Filed:

Dec. 04, 2013
Applicants:

Yongjun Guan, Clarksville, MD (US);

George Lewis, Baltimore, MD (US);

Anthony Devico, Alexandria, VA (US);

Mohammad Sajadi, Cockeysville, MD (US);

Tongyun Liu, Abingdon, MD (US);

Marzena Pazgier, Mt. Airy, MD (US);

Inventors:

Yongjun Guan, Clarksville, MD (US);

George Lewis, Baltimore, MD (US);

Anthony Devico, Alexandria, VA (US);

Mohammad Sajadi, Cockeysville, MD (US);

Tongyun Liu, Abingdon, MD (US);

Marzena Pazgier, Mt. Airy, MD (US);

Assignee:

UNIVERSITY OF MARYLAND, BALTIMORE, Baltimore, MD (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07K 14/005 (2006.01); C07K 14/16 (2006.01); C07K 16/10 (2006.01); A61K 39/12 (2006.01); A61K 39/21 (2006.01); A61K 39/00 (2006.01);
U.S. Cl.
CPC ...
C07K 14/005 (2013.01); A61K 39/12 (2013.01); C07K 14/162 (2013.01); C07K 16/1063 (2013.01); A61K 39/21 (2013.01); A61K 2039/505 (2013.01); C07K 2317/31 (2013.01); C07K 2317/34 (2013.01); C07K 2317/56 (2013.01); C07K 2317/622 (2013.01); C07K 2317/76 (2013.01); C07K 2318/10 (2013.01); C07K 2319/00 (2013.01); C07K 2319/40 (2013.01); C12N 2740/16134 (2013.01);
Abstract

Fusion proteins comprising a portion of the HIV-1 Env protein (gp120 and gp140) and single-chain fragment V regions (ScFv) of an enhancing antibody that exhibits binding specificity for HIV-1 Env protein are disclosed that may serve in immunogenic formulations for vaccination against HIV-1 infection, as well as methods of generating an immune response using the fusion proteins.


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