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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 9949981 B1

PDFFull Text
Date of Patent:
Apr. 24, 2018

Filed:

Sep. 04, 2015

Compositions and methods for treating proliferation disorders

Applicant:

Arqule, Inc., Burlington, MA (US);

Inventors:

Daniel T. Dransfield, Burlington, MA (US);

Sudharshan Eathiraj, Shrewsbury, MA (US);

Jean-Marc Lapierre, Pelham, NH (US);

Brian Schwartz, Woodbridge, CT (US);

Yi Yu, North Easton, MA (US);

Assignee:

ArQule, Inc., Burlington, MA (US);

Attorneys:

Cooley LLP

Matthew Pavao

Chen Chen

Primary Examiner:

Kara R McMillian

Int. Cl.
CPC ...
A61K 31/5377 (2006.01); A61K 31/444 (2006.01); A61K 31/4545 (2006.01); A61K 45/06 (2006.01); A61K 31/517 (2006.01);
U.S. Cl.
CPC ...
A61K 31/5377 (2013.01); A61K 31/444 (2013.01); A61K 31/4545 (2013.01); A61K 31/517 (2013.01); A61K 45/06 (2013.01);
Abstract

The present invention relates to methods of treating cell proliferative disorders, such as cancer or Proteus syndrome, by utilizing 3-(3-(4-(1-aminocyclobutyl)phenyl)-5-phenyl-3H-imidazo[4,5-b]pyridin-2-yl)pyridin-2-amine or 3-(3-(4-(1-aminocyclobutyl)phenyl)-5-(3-morpholinophenyl)-3H-imidazo[4,5-b]pyridin-2-yl)pyridin-2-amine or N-(1-(3-(3-(4-(1-aminocyclobutyl)phenyl)-2-(2-aminopyridin-3-yl)-3H-imidazo[4,5-b]pyridin-5-yl)phenyl)piperidin-4-yl)-N-methylacetamide. The methods of the present invention can also relate to methods of treating cell proliferative disorders, such as cancer or Proteus syndrome, by utilizing the above compounds in combination with ((R)-6-(2-fluorophenyl)-N-(3-(2-((2-methoxyethyl)amino)ethyl)phenyl)-5,6-dihydrobenzo[h]quinazolin-2-amine).

Find Patent Forward Citations

Dransfield, Daniel. (2018). Compositions and methods for treating proliferation disorders (U.S. Patent No. 9949981). U.S. Patent and Trademark Office. https://idiyas.com/patent/badge/9949981

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