The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 17, 2018
Filed:
May. 24, 2011
Lin Ji, Sugar Land, TX (US);
John Dorrance Minna, Dallas, TX (US);
Jack Roth, Houston, TX (US);
Michael Lerman, Rockville, MD (US);
Lin Ji, Sugar Land, TX (US);
John Dorrance Minna, Dallas, TX (US);
Jack Roth, Houston, TX (US);
Michael Lerman, Rockville, MD (US);
Board of Regents, The University of Texas System, Austin, TX (US);
The United States of America as represented by the Secretary of the Department of Health and Human Services, Washington, DC (US);
Abstract
Tumor suppressor genes play a major role in the pathogenesis of human lung cancer and other cancers. Cytogenetic and allelotyping studies of fresh tumor and tumor-derived cell lines showed that cytogenetic changes and allele loss on the short arm of chromosome 3 (3p) are most frequently involved in about 90% of small cell lung cancers and greater than 50% of non-small cell lung cancers. A group of recessive oncogenes, Fus1, 101F6, Gene 21 (NPRL2), Gene 26 (CACNA2D2), Luca 1 (HYAL1), Luca 2 (HYAL2), PL6, 123F2 (RaSSFI), SEM A3 and Beta* (BLU), as defined by homozygous deletions in lung cancers, have been located and isolated at 3p21.3.