The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 10, 2018
Filed:
Dec. 27, 2013
Drexel University, Philadelphia, PA (US);
Baruch S. Blumberg Institute, Doylestown, PA (US);
Arbutus Biopharma, Inc., Doylestown, PA (US);
Xiaodong Xu, Doylestown, PA (US);
Ju-Tao Guo, Lansdale, PA (US);
Tong Xiao, Edison, NJ (US);
Yanming Du, Cheshire, CT (US);
Timothy Block, Doylestown, PA (US);
Simon David Peter Baugh, Ringoes, NJ (US);
Hong Ye, Lansdale, PA (US);
Drexel University, Philadelphia, PA (US);
Baruch S. Blumberg Institute, Doylestown, PA (US);
Arbutus Biopharma, Inc., Warminster, PA (US);
Abstract
The present invention provides novel compounds of formula (I) and methods of use thereof. In certain embodiments, the compounds of the invention are useful as nucleocapsid assembly inhibitors. In other embodiments, the compounds of the invention are useful as pregenomic RNA encapsidation inhibitors of Hepatitis B virus (HBV). In yet other embodiments, the compounds of the invention are useful for the treatment of viral infection, including HBV and related viral infections.