The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 13, 2018
Filed:
Dec. 28, 2015
Applicants:
Ingeneron, Inc., Houston, TX (US);
Alliance of Cardiovascular Researchers, New Orleans, LA (US);
Inventors:
Eckhard Alt, Houston, TX (US);
Tahereh Karimi, Houston, TX (US);
Assignees:
InGeneron Inc., Houston, TX (US);
Alliance of Cardiovascular Research, New Orleans, LA (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12N 5/00 (2006.01); A61K 35/34 (2015.01); C12N 5/077 (2010.01); C12N 5/079 (2010.01); A61K 35/30 (2015.01);
U.S. Cl.
CPC ...
A61K 35/34 (2013.01); A61K 35/30 (2013.01); C12N 5/0618 (2013.01); C12N 5/0657 (2013.01); C12N 2501/60 (2013.01); C12N 2501/998 (2013.01); C12N 2506/08 (2013.01); C12N 2506/1384 (2013.01); C12N 2510/00 (2013.01);
Abstract
Adult stem cells are reprogrammed to form pacemaker cells and Purkinje cells through the sequential activation of SHOX2>TBX5>HCN2. These Purkinje cells spontaneously surround and connect with the larger pacemaker cells, thus forming an induced sinoatrial body that produces funny current and can make cardiovascular tissues beat in a manner similar to a natural sinoatrial node.