The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Mar. 06, 2018

Filed:

Aug. 06, 2008
Applicants:

Samir M. Mitragotri, Santa Barbara, CA (US);

Sumit Paliwal, Goleta, CA (US);

Makoto Ogura, Goleta, CA (US);

Inventors:

Samir M. Mitragotri, Santa Barbara, CA (US);

Sumit Paliwal, Goleta, CA (US);

Makoto Ogura, Goleta, CA (US);

Assignee:
Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
G01N 1/00 (2006.01); A61K 9/10 (2006.01); A61K 49/00 (2006.01); C12M 1/33 (2006.01); G01N 1/28 (2006.01);
U.S. Cl.
CPC ...
C12M 45/02 (2013.01); G01N 1/286 (2013.01);
Abstract

The current invention provides methods, as well as compositions useful in such methods, involving application of energy to a tissue of interest to generate a liquefied sample comprising tissue constituents so as to provide for rapid tissue sampling, as well as qualitative and/or quantitative detection of analytes that may be part of tissue constituents (e.g., several types of biomolecules, drugs, and microbes). Determination of tissue composition can be used in a variety of applications, including diagnosis or prognosis of local as well as systemic diseases, evaluating bioavailability of therapeutics in different tissues following drug administration, forensic detection of drugs-of-abuse, evaluating changes in the tissue microenvironment following exposure to a harmful agent, and various other applications.


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