The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 06, 2018
Filed:
Jan. 31, 2014
Applicant:
The Washington University, St. Louis, MO (US);
Inventors:
Lester Smith, St. Louis, MO (US);
Stavros Thomopoulos, St. Louis, MO (US);
Assignee:
WASHINGTON UNIVERSITY, Saint Louis, MO (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07K 14/78 (2006.01); A61K 38/39 (2006.01); A61L 27/12 (2006.01); A61L 27/24 (2006.01); A61L 27/46 (2006.01);
U.S. Cl.
CPC ...
C07K 14/78 (2013.01); A61K 38/39 (2013.01); A61L 27/12 (2013.01); A61L 27/24 (2013.01); A61L 27/46 (2013.01); A61L 2430/10 (2013.01);
Abstract
A mineralized collagen matrix with an intrafibrillar and/or extrafibrillar gradient of mineralization for insertion replacement is disclosed. The intrafibrillar mineralization of the collagen matrix is formed by the addition of fetuin to the simulated body fluid. The gradient of intrafibrillar mineralization may stiffen the collagen matrix and simulate a natural insertion for improved cell infiltration and regeneration.