The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 13, 2018
Filed:
May. 26, 2017
Applicant:
Precision Biosciences, Inc., Durham, NC (US);
Inventors:
Derek Jantz, Durham, NC (US);
James Jefferson Smith, Morrisville, NC (US);
Michael G. Nicholson, Chapel Hill, NC (US);
Daniel T. MacLeod, Durham, NC (US);
Victor Bartsevich, Durham, NC (US);
Jeyaraj Antony, Chapel Hill, NC (US);
Assignee:
Precision BioSciences, Inc., Durham, NC (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 35/17 (2015.01); C07K 16/30 (2006.01); C12N 15/09 (2006.01); A61K 39/00 (2006.01); C12N 5/0783 (2010.01); C12N 15/113 (2010.01); C12N 15/86 (2006.01); A61K 48/00 (2006.01); C07K 14/705 (2006.01); C07K 14/725 (2006.01);
U.S. Cl.
CPC ...
A61K 35/17 (2013.01); A61K 39/0011 (2013.01); A61K 48/0008 (2013.01); C07K 14/7051 (2013.01); C07K 14/70503 (2013.01); C07K 16/30 (2013.01); C07K 16/3061 (2013.01); C12N 5/0636 (2013.01); C12N 15/09 (2013.01); C12N 15/113 (2013.01); C12N 15/86 (2013.01); A61K 2039/505 (2013.01); A61K 2039/5156 (2013.01); A61K 2039/5158 (2013.01); C07K 2317/53 (2013.01); C07K 2319/02 (2013.01); C07K 2319/03 (2013.01); C07K 2319/33 (2013.01); C07K 2319/40 (2013.01); C07K 2319/74 (2013.01); C12N 2510/00 (2013.01);
Abstract
Disclosed herein is a genetically-modified cell comprising in its genome a modified human T cell receptor alpha constant region gene, wherein the cell has reduced cell-surface expression of the endogenous T cell receptor. The present disclosure further relates to methods for producing such a genetically-modified cell, and to methods of using such a cell for treating a disease in a subject.