The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Feb. 13, 2018

Filed:

Apr. 04, 2014
Applicant:

The Trustees of Columbia University IN the City of New York, New York, NY (US);

Inventors:

Gordana Vunjak-Novakovic, New York, NY (US);

Joshua Sonett, Ho Ho Kus, NJ (US);

John O'Neill, New York, NY (US);

Matthew Bacchetta, New York, NY (US);

Donald O. Freytes, Summit, NJ (US);

Gopal Singh, New York, NY (US);

Scott A. Kanner, Brooklyn, NY (US);

Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
A01N 1/00 (2006.01); A01N 1/02 (2006.01);
U.S. Cl.
CPC ...
A01N 1/0247 (2013.01); A01N 1/0226 (2013.01);
Abstract

The vasculature of a donor lung is perfused with a lung preserving fluid to preserve its structure. At the same time, a decellularization fluid is perfused through the airways, which strips away donor cells. The decellularized region is then seeded with pulmonary cells of the transplant recipient, which regenerate the lung. The pulmonary cells may be derived from stem cells, and the decellularization can be targeted to reduce the quantity of cells required.


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