The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 26, 2017
Filed:
Feb. 03, 2014
Applicant:
National University Corporation Kyoto Institute of Technology, Kyoto, JP;
Inventors:
Yoichi Kumada, Kyoto, JP;
Yasuyuki Ishikawa, Kyoto, JP;
Yusuke Fujiwara, Kyoto, JP;
Michimasa Kishimoto, Kyoto, JP;
Assignee:
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07K 16/18 (2006.01); C07K 16/26 (2006.01); C07K 17/14 (2006.01); C07K 17/08 (2006.01); C07K 16/42 (2006.01); C07K 16/06 (2006.01); C07K 16/30 (2006.01); C07K 16/40 (2006.01); C08F 122/10 (2006.01);
U.S. Cl.
CPC ...
C07K 16/4241 (2013.01); C07K 16/065 (2013.01); C07K 16/18 (2013.01); C07K 16/26 (2013.01); C07K 16/3007 (2013.01); C07K 16/40 (2013.01); C07K 17/08 (2013.01); C08F 122/10 (2013.01); C07K 2317/14 (2013.01); C07K 2317/40 (2013.01); C07K 2317/622 (2013.01); C07K 2319/35 (2013.01);
Abstract
A method for refolding an antibody, a process for producing a refolded antibody, a refolded antibody, and uses thereof are provided. A method for refolding an antibody in a liquid phase comprises the steps of denaturing an inactive antibody binding directly or through a linker to a peptide, the peptide having an isoelectric point lower than the isoelectric point of the inactive antibody, and dispersing in a liquid phase the peptide-binding inactive antibody denatured in the step above. Also provided is a process for producing a refolded antibody.