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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 9840481 B1

PDFFull Text
Date of Patent:
Dec. 12, 2017

Filed:

Mar. 20, 2017

Allosteric modulators of nicotinic acetylcholine receptors

Applicant:

Merck Sharp & Dohme Corp., Rahway, NJ (US);

Inventors:

Brendan M. Crowley, Collegeville, PA (US);

Brian T. Campbell, Bensalem, PA (US);

Joseph L. Duffy, Cranford, NJ (US);

Thomas J. Greshock, Collegeville, PA (US);

Deodial G. Guiadeen, Chesterfield, NJ (US);

Andrew John Harvey, Paddington, AU;

Belinda C. Huff, Thebarton SA, AU;

Kenneth J. Leavitt, Mount Laurel, NJ (US);

Vanessa L. Rada, Hatfield, PA (US);

John M. Sanders, Hatfield, PA (US);

William D. Shipe, Chalfont, PA (US);

Linda M. Suen, Philadelphia, PA (US);

Ian M. Bell, Harleysville, PA (US);

Assignee:

Merck Sharp & Dohme Corp., Rahway, NJ (US);

Attorneys:

Matthew A. Leff

John C. Todaro

Primary Examiner:

Timothy R Rozof

Int. Cl.
CPC ...
C07D 285/12 (2006.01); C07D 231/12 (2006.01); C07D 249/04 (2006.01); C07D 261/08 (2006.01); C07D 263/32 (2006.01); C07D 271/06 (2006.01); C07D 271/07 (2006.01); C07D 277/26 (2006.01); C07D 285/08 (2006.01); A61K 31/4245 (2006.01); A61K 31/433 (2006.01); C07D 271/107 (2006.01); A61K 31/421 (2006.01); A61K 31/42 (2006.01); A61K 31/4192 (2006.01); A61K 31/415 (2006.01); A61K 31/426 (2006.01);
U.S. Cl.
CPC ...
C07D 285/12 (2013.01); A61K 31/415 (2013.01); A61K 31/4192 (2013.01); A61K 31/42 (2013.01); A61K 31/421 (2013.01); A61K 31/426 (2013.01); A61K 31/4245 (2013.01); A61K 31/433 (2013.01); C07D 231/12 (2013.01); C07D 249/04 (2013.01); C07D 261/08 (2013.01); C07D 263/32 (2013.01); C07D 271/06 (2013.01); C07D 271/107 (2013.01); C07D 277/26 (2013.01); C07D 285/08 (2013.01);
Abstract

The present disclosure relates to compounds of formula I that are useful as modulators of α7 nAChR, compositions comprising such compounds, and the use of such compounds for preventing, treating, or ameliorating disease, particularly disorders of the central nervous system such as cognitive impairments in Alzheimer's disease, Parkinson's disease, and schizophrenia, as well as for L-DOPA induced-dyskinesia and inflammation

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