The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 28, 2017
Filed:
Feb. 25, 2016
Applicant:
Idera Pharmaceuticals, Inc., Cambridge, MA (US);
Inventors:
Sudhir Agrawal, Shrewsbury, MA (US);
Wayne Jiang, Waltham, MA (US);
Daqing Wang, Bedford, MA (US);
Jessica Seitzer, Windham, NH (US);
Fu-Gang Zhu, Bedford, MA (US);
Xianzhi Mao, Ambler, PA (US);
Assignee:
IDERA PHARMACEUTICALS, INC., Cambridge, MA (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07H 21/04 (2006.01); C12N 15/11 (2006.01); A61K 31/7105 (2006.01); A61K 45/06 (2006.01); C12N 15/113 (2010.01);
U.S. Cl.
CPC ...
C12N 15/11 (2013.01); A61K 31/7105 (2013.01); A61K 45/06 (2013.01); C12N 15/1138 (2013.01); C12N 2310/11 (2013.01); C12N 2310/314 (2013.01); C12N 2310/51 (2013.01);
Abstract
The present invention is directed to compounds, compositions, and methods useful for modulating PD1, PDL1, IDO1, LAG3, TIM3, CTLA4, IDO2, CEACAM1, OX40, and/or OX40L mRNA or protein expression using gene silencing compounds comprising two or more single stranded antisense oligonucleotides that are linked through their 5'-ends to allow the presence of two or more accessible 3′-ends.