The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 28, 2017
Filed:
Oct. 11, 2013
Nattopharma R&d Ltd, Nicosia, CY;
Krzysztof Krajewski, Warsaw, PL;
Andrzej Kutner, Warsaw, PL;
Jadwiga Dzikowska, Blonie, PL;
Regina Gutowska, Sieraków, PL;
Marek Napiórkowski, Warsaw, PL;
Jerzy Winiarski, Warsaw, PL;
Marek Kubiszewski, Iłow, PL;
Łukasz Jedynak, Sosnowiec, PL;
Jacek Morzycki, Białystok, PL;
Stanislaw Witkowski, Białystok, PL;
Aneta Baj, Białystok, PL;
Piotr Wałejko, Białystok, PL;
Nattopharma R & D Ltd., Nicosia, CY;
Abstract
Process for preparation of MK-7 type of vitamin K2 is characterized by attaching hexaprenyl chain of 'all-trans' configuration to monoprenyl derivative of menadiol following '1+6' synthetic strategy. According to the invention, a-sulfonyl carbanion generated in situ from the protected monoprenyl menadiol of the formula (II), wherein Rrepresents C-alkyl group, is reacted with hexaprenyl halide of the formula (VII), wherein X represents halogen atom, preferably bromine, both Z' and Z′ represent H or one of Z′ and Z″ represents H and the other represents phenylsulfonyl group —SOPh in the alkylation reaction. The hexaprenyl halide of formula (VII) is obtained by coupling two triprenyl units in alkylation reaction, with or without separation of the intermediates.