The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 21, 2017
Filed:
Jun. 01, 2017
King Saud University, Riyadh, SA;
Assem Barakat, Riyadh, SA;
Mohammad Shahidul Islam, Riyadh, SA;
Abdullah Mohammed Al Majid, Riyadh, SA;
Hussain Mansur Ghawas, Riyadh, SA;
Fardous F. El-Senduny, Mansoura, EG;
Farid A. Badria, Mansoura, EG;
Yaseen Ali Mosa Mohamed Elshaier, Assuit, EG;
Hazem A. Ghabbour, Riyadh, SA;
Other;
Abstract
The substituted spirooxindoles are MDM2-p53 inhibitors bearing a benzylidine (styryl) arm and have a complex fused ring system ideally suited for binding to the MDM2 protein, thereby interrupting its protein-protein interaction (PPI). Sixteen compounds, designated 4a-4p, were synthesized in a simple smooth method using an asymmetric 1,3-dipolar reaction as the key step. Testing showed that the compounds exhibit anti-cancer activity against various forms of cancer cells affecting humans.