The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Nov. 14, 2017

Filed:

Dec. 17, 2014
Applicants:

Merck Sharp & Dohme Corp., Rahway, NJ (US);

Msd R & D (China) Co. Ltd., Shanghai, CN;

Inventors:

Dong Ming Shen, Edison, NJ (US);

Melissa Egbertson, Ambler, PA (US);

Richard Berger, Harleysville, PA (US);

XiaoXia Qian, New York, NY (US);

Yimin Qian, Plainsboro, NJ (US);

Bart Harper, New York, NY (US);

Meng Yang, Westfield, NJ (US);

Zack Zhiqiang Guo, Morganville, NJ (US);

Vanessa L. Rada, Hatfield, PA (US);

Deping Wang, Furlong, PA (US);

Timothy A. Cernak, Boston, MA (US);

Christopher Sinz, Middletown, NJ (US);

Ming Wang, Belle Mead, NJ (US);

Jonathan E. Wilson, South Orange, NJ (US);

Shimin Xu, Beijing, CN;

Assignees:

Merck Sharp & Dohme Corp., Rahway, NJ (US);

MSD R & D (China) Co. LTD., Shanghai, CN;

Attorneys:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C07D 239/36 (2006.01); C07D 401/12 (2006.01); C07D 401/06 (2006.01); C07D 403/04 (2006.01); C07D 403/14 (2006.01); C07D 487/04 (2006.01); C07D 405/12 (2006.01); C07D 405/14 (2006.01); C07D 413/04 (2006.01); C07D 417/04 (2006.01); C07D 403/12 (2006.01); C07D 403/06 (2006.01);
U.S. Cl.
CPC ...
C07D 239/36 (2013.01); C07D 401/06 (2013.01); C07D 401/12 (2013.01); C07D 403/04 (2013.01); C07D 403/06 (2013.01); C07D 403/12 (2013.01); C07D 403/14 (2013.01); C07D 405/12 (2013.01); C07D 405/14 (2013.01); C07D 413/04 (2013.01); C07D 417/04 (2013.01); C07D 487/04 (2013.01);
Abstract

Disclosed are pyrimidine carboxamide compounds of formula (I) which are useful as therapeutic agents for the treatment of central nervous system disorders associated with phosphodiesterase 2 (PDE2), pharmaceutical compositions and uses thereof.


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