The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 07, 2017
Filed:
Apr. 30, 2013
The University of Tokyo, Tokyo, JP;
Nanocarrier Co., Ltd., Kashiwa-shi, JP;
Kazunori Kataoka, Tokyo, JP;
Kanjiro Miyata, Tokyo, JP;
Nobuhiro Nishiyama, Tokyo, JP;
Kensuke Osada, Tokyo, JP;
Sumiyo Watanabe, Tokyo, JP;
Shigeto Fukushima, Tokyo, JP;
Hiroyuki Chaya, Tokyo, JP;
Hiroyasu Takemoto, Tokyo, JP;
Yasuki Kato, Kashiwa, JP;
NANOCARRIER CO., LTD., Kashiwa-shi, JP;
THE UNIVERSITY OF TOKYO, Tokyo, JP;
Abstract
A unit structure-type pharmaceutical composition includes at least one nucleic acid, such as siRNA, electrostatically bound to at least one block copolymer having a cationic polyamino acid segment and a hydrophilic polymer chain segment. The negative charge(s) of the nucleic acid are counterbalanced, at least substantially, by the positive charge(s) of the cationic polyamino acid segment such that the pharmaceutical composition is electrically neutral or nearly electrically neutral. Further, the nucleic acid is covered with the hydrophilic polymer chain segment(s). The at least one block copolymer thereby improves the blood retention capability of the nucleic acid(s).