The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 24, 2017
Filed:
May. 22, 2015
Ulrich M. Lauer, Tuebingen, DE;
Michael Bitzer, Rottenburg, DE;
Johanna Lampe, Helsinki, FI;
Martina Schell, Tuebingen, DE;
Susanne Berchtold, Tuebingen, DE;
Sebastian Lange, Tuebingen, DE;
Wolfgang J. Neubert, Greifenberg, DE;
Sascha Bossow, Heidelberg, DE;
Ulrich M. Lauer, Tuebingen, DE;
Michael Bitzer, Rottenburg, DE;
Johanna Lampe, Helsinki, FI;
Martina Schell, Tuebingen, DE;
Susanne Berchtold, Tuebingen, DE;
Sebastian Lange, Tuebingen, DE;
Wolfgang J. Neubert, Greifenberg, DE;
Sascha Bossow, Heidelberg, DE;
Other;
Abstract
The present invention pertains to a pharmaceutical composition comprising a recombinant measles virus encoding a suicide gene for use in the treatment of malignant cells with primary or secondary resistances against an oncolytic measles virus without suicide gene activity. Further, the present invention pertains to a recombinant measles virus based on measles vaccine strain Schwarz encoding a suicide gene, which comprises a fusion of a cytosine deaminase, particularly yeast cytosine deaminase, and a uracil phosphoribosyltransferase, particularly yeast uracil phosphoribosyltransferase, to a method and a kit for preparing the recombinant measles virus as claimed herein.