The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 17, 2017
Filed:
Sep. 14, 2012
Applicants:
Giovanni Monteleone, Grottaferrata, IT;
Francesca Viti, Salorino, CH;
Salvatore Bellinvia, Balerna, CH;
Inventors:
Giovanni Monteleone, Grottaferrata, IT;
Francesca Viti, Salorino, CH;
Salvatore Bellinvia, Balerna, CH;
Assignee:
Nogra Pharma Limited, Dublin, IE;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
G01N 33/569 (2006.01); G01N 33/68 (2006.01); G01N 33/50 (2006.01);
U.S. Cl.
CPC ...
G01N 33/56972 (2013.01); G01N 33/505 (2013.01); G01N 33/5094 (2013.01); G01N 33/6866 (2013.01); G01N 33/6869 (2013.01); G01N 33/6872 (2013.01); G01N 2333/54 (2013.01); G01N 2333/7158 (2013.01); G01N 2800/065 (2013.01); G01N 2800/52 (2013.01);
Abstract
Methods for monitoring whether a subject will be sensitive or resistant to treatment with an anti-SMAD7 therapy are disclosed. The methods are based on the determining of the amount of CCR9+ FOXP3+ T cells, CCR9+ IFN-gamma+ T cells, CCR9+ IL17A+ T cells, FOXP3+ T cells, IFN-gamma+ T cells, and/or IL17A+ T cells in a sample from the subject. Measurement of T cell populations may be determined by flow cytometry, immunohistochemistry, and/or ELISA.