The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 10, 2017
Filed:
Jul. 31, 2013
Applicant:
Basilea Pharmaceutica Ag, Basel, CH;
Inventors:
Ruben Van Summeren, Weert, NL;
Harrie Vaessen, Wijnandsrade, NL;
Daniel Mink, Eupen, BE;
Mario Waser, Leonding, AT;
Assignee:
Basilea Pharmaceutica AG, Basel, CH;
Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C07D 249/08 (2006.01);
U.S. Cl.
CPC ...
C07D 249/08 (2013.01);
Abstract
The invention relates to a process for the manufacture of diastereomerically and enantiomerically enriched triazole compounds isavuconazole and ravuconazole, comprising a Reformatsky reaction between a ketone and a 2-halozincpropionate ester, followed by a resolution step, preferably an enzymatic resolution with an esterase enzyme.