The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 03, 2017
Filed:
Jan. 13, 2011
Gary H. Posner, Baltimore, MD (US);
Lindsey C. Hess, Pflugerville, TX (US);
Alvin S. Kalinda, Bloomington, IN (US);
Rachel D. Slack, Baltimore, MD (US);
Uttam Saha, Thornhill, CA;
P. Martin Petkovich, Kingston, CA;
Gary H. Posner, Baltimore, MD (US);
Lindsey C. Hess, Pflugerville, TX (US);
Alvin S. Kalinda, Bloomington, IN (US);
Rachel D. Slack, Baltimore, MD (US);
Uttam Saha, Thornhill, CA;
P. Martin Petkovich, Kingston, CA;
JOHNS HOPKINS UNIVERSITY, Baltimore, MD (US);
OPKO IRELAND GLOBAL HOLDINGS, LTD., Grand Cayman, KY;
Abstract
This present disclosure is directed to novel prodrugs of activated vitamin D3 compounds. The prodrugs can be designed to have one or more beneficial properties, such as selective inhibition of the enzyme CYP24, low calcemic activity, and anti-proliferative activity. Specifically, these prodrugs are 1-deoxy prohormones of active Vitamin D analogs, e.g. analogs of calcitriol. This disclosure is also directed to pharmaceutical and diagnostic compositions containing the prodrugs of the invention, and to their medical use, particularly as prodrugs in the treatment and/or prevention of diseases.