The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 26, 2017
Filed:
Aug. 25, 2015
Ionis Pharmaceuticals, Inc., Carlsbad, CA (US);
Brenda F. Baker, Carlsbad, CA (US);
Anne B. Eldrup, Newtown, CT (US);
Muthiah Manoharan, Weston, MA (US);
Balkrishen Bhat, Carlsbad, CA (US);
Richard H. Griffey, Vista, CA (US);
Eric E. Swayze, Encinitas, CA (US);
Thazha P. Prakash, Carlsbad, CA (US);
Ionis Pharmaceuticals, Inc., Carlsbad, CA (US);
Abstract
Oligonucleotide compositions comprising first and second oligonucleotides are provided wherein at least a portion of the first oligonucleotide is capable of hybridizing with at least a portion of the second oligonucleotide, at least a portion of the first oligonucleotide is complementary to and capable of hybridizing to a selected target nucleic acid, and at least one of the first or second oligonucleotides includes at least one nucleotide having a modified phosphorous-containing internucleoside linkage. Oligonucleotide/protein compositions are also provided comprising an oligonucleotide complementary to and capable of hybridizing to a selected target nucleic acid and at least one protein comprising at least a portion of an RNA-induced silencing complex (RISC), wherein at least one nucleotide of the oligonucleotide has a modified phosphorous-containing internucleoside linkage.