The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 19, 2017
Filed:
Jul. 31, 2015
Amgen Inc., Thousand Oaks, CA (US);
Amgen Research (Munich) Gmbh, Munich, DE;
Shouhua Xiao, Foster City, CA (US);
Zheng Pan, Fremont, CA (US);
Dineli Wickramasinghe, San Francisco, CA (US);
Peter Kufer, Munich, DE;
Patrick Hoffmann, Munich, DE;
Tobias Raum, Munich, DE;
Ralf Lutterbüse, Munich, DE;
Elisabeth Nahrwold, Munich, DE;
Claudia Blumel, Munich, DE;
AMGEN RESEARCH (MUNICH) GMBH, Munich, DE;
Abstract
The present invention provides a bispecific antibody construct comprising a first human binding domain which binds to human CDH19 on the surface of a target cell and a second binding domain which binds a human CD3 on the surface of a T cell. Moreover, the invention provides a polynucleotide encoding the antibody construct, a vector comprising the polynucleotide and a host cell transformed or transfected with the polynucleotide or vector. Furthermore, the invention provides a process for the production of the antibody construct of the invention, a medical use of the antibody construct in the treatment of melanoma, and a kit comprising the antibody construct.