The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 19, 2017
Filed:
Jul. 20, 2012
Anna M. Wu, Sherman Oaks, CA (US);
John E. Shively, Arcadia, CA (US);
Andrew A. Raubitschek, San Marino, CA (US);
Mark A. Sherman, Pasadena, CA (US);
Tove Olafsen, Sherman Oaks, CA (US);
Anna M. Wu, Sherman Oaks, CA (US);
John E. Shively, Arcadia, CA (US);
Andrew A. Raubitschek, San Marino, CA (US);
Mark A. Sherman, Pasadena, CA (US);
Tove Olafsen, Sherman Oaks, CA (US);
City of Hope, Duarte, CA (US);
Abstract
The present invention provides recombinant antibody fragments which include a variable domain which has been modified by the addition of a tail sequence to its C-terminal end. The tail sequence comprises a terminal cysteine residue and an amino acid spacer and does not substantially affect the fragment's target-binding affinity. The present invention also provides pharmaceutical compositions comprising the described antibody fragments and a pharmaceutically acceptable carrier and methods of delivering an agent to cells of interest in a subject using the fragments as delivery vehicles. The invention further provides compositions comprising the described antibody fragments for the in vitro detection and measurement of target molecules which bind to the fragments and method of determining the presence or amount of such targets in a biological sample by contacting the sample with such compositions.