The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 12, 2017
Filed:
Dec. 18, 2015
Applicants:
Drexel University, Philadelphia, PA (US);
Baruch S. Blumberg Institute, Doylestown, PA (US);
Inventors:
Ju-Tao Guo, Lansdale, PA (US);
Xiaodong Xu, Doylestown, PA (US);
Timothy M. Block, Doylestown, PA (US);
Assignees:
Drexel University, Philadelphia, PA (US);
Baruch S. Blumberg Institute, Doylestown, PA (US);
Primary Examiner:
Int. Cl.
CPC ...
A61K 31/55 (2006.01); A61K 31/47 (2006.01); A61K 31/18 (2006.01); C07C 311/46 (2006.01); A61K 31/341 (2006.01); C07D 281/16 (2006.01); C07D 295/26 (2006.01); C07D 213/40 (2006.01); C07D 307/52 (2006.01); C07D 307/68 (2006.01); C07D 211/96 (2006.01); C07D 223/04 (2006.01); A61K 31/167 (2006.01); A61K 31/4406 (2006.01); A61K 31/4453 (2006.01); A61K 31/5375 (2006.01); A61K 31/54 (2006.01); A61K 31/553 (2006.01); A61K 31/44 (2006.01); A61K 31/541 (2006.01); A61K 31/445 (2006.01); A61K 31/5377 (2006.01);
U.S. Cl.
CPC ...
C07C 311/46 (2013.01); A61K 31/167 (2013.01); A61K 31/18 (2013.01); A61K 31/341 (2013.01); A61K 31/4406 (2013.01); A61K 31/4453 (2013.01); A61K 31/5375 (2013.01); A61K 31/54 (2013.01); A61K 31/55 (2013.01); A61K 31/553 (2013.01); C07D 211/96 (2013.01); C07D 213/40 (2013.01); C07D 223/04 (2013.01); C07D 281/16 (2013.01); C07D 295/26 (2013.01); C07D 307/52 (2013.01); C07D 307/68 (2013.01); A61K 31/44 (2013.01); A61K 31/445 (2013.01); A61K 31/5377 (2013.01); A61K 31/541 (2013.01); A61K 2300/00 (2013.01);
Abstract
The present invention provides sulfamoylbenzamide derivatives, and pharmaceutical compositions thereof. In certain embodiments, the compounds and pharmaceutical compositions of the invention inhibit pregenomic RNA encapsidation. In other embodiments, the compounds and pharmaceutical compositions of the invention are useful for treating Hepatitis B virus (HBV) infection.