The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Sep. 05, 2017

Filed:

Nov. 09, 2016
Applicant:

Millennium Pharmaceuticals, Inc., Cambridge, MA (US);

Inventors:

Indu T. Bharathan, Cambridge, MA (US);

Chris Blackburn, Natick, MA (US);

Jeffrey P. Ciavarri, Reading, MA (US);

Jouhara Chouitar, Stoughton, MA (US);

Courtney A. Cullis, Bedford, MA (US);

Natalie D'Amore, Lynnfield, MA (US);

Paul E. Fleming, Wellesley, MA (US);

Kenneth M. Gigstad, Westford, MA (US);

Krista E. Gipson, Medford, MA (US);

Mario Girard, Quincy, MA (US);

Yongbo Hu, Winchester, MA (US);

Janice Lee, Cambridge, MA (US);

Gang Li, Westborough, MA (US);

Mansoureh Rezaei, Quincy, MA (US);

Michael D. Sintchak, Winchester, MA (US);

Francois Soucy, Stoneham, MA (US);

Stephen G. Stroud, Medford, MA (US);

Tricia J. Vos, Boston, MA (US);

Tzu-Tshin Wong, Acton, MA (US);

He Xu, Needham, MA (US);

Tianlin Xu, Shrewsbury, MA (US);

Yingchun Ye, Belmont, MA (US);

Assignee:

Millennium Pharmaceuticals, Inc., Cambridge, MA (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07D 401/04 (2006.01); C07D 513/04 (2006.01); A61K 31/444 (2006.01); A61K 45/06 (2006.01); C07D 417/14 (2006.01); C07D 401/14 (2006.01); A61K 31/506 (2006.01); C07D 471/04 (2006.01); A61K 31/437 (2006.01); A61K 31/549 (2006.01); A61K 31/497 (2006.01);
U.S. Cl.
CPC ...
C07D 401/04 (2013.01); A61K 31/437 (2013.01); A61K 31/444 (2013.01); A61K 31/497 (2013.01); A61K 31/506 (2013.01); A61K 31/549 (2013.01); A61K 45/06 (2013.01); C07D 401/14 (2013.01); C07D 417/14 (2013.01); C07D 471/04 (2013.01); C07D 513/04 (2013.01);
Abstract

The present invention provides a compound of formula I: and pharmaceutically acceptable salts thereof, wherein X, R, R, R, R, R, L, L, m, and n, are as described in the specification. Such compounds are inhibitors of VPS34 and thus useful for treating proliferative, inflammatory, or cardiovascular disorders.


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